Attorneys for President Barack Obama will seek to stave off the biggest legal challenge yet to health-care reform on Wednesday. The administration will present oral arguments as it appeals a ruling by a Florida judge who declared the Patient Protection and Affordable Care Act unconstitutional, backing claims by 26 states, including Iowa, that are seeking to invalidate it.

A three-judge panel at the 11th Circuit Court of Appeals in Atlanta will hear oral arguments by both sides. Though a Virginia appeals court heard a similar case in May, this case is significant because of the number of states backing it.

Chief Judge Joel Dubina, Judge Frank Hull and Judge Stanley Marcus in Atlanta will hear the appeal. Analysts will watch their questions closely for clues as to how they might rule. Dubina was appointed by President George H. W. Bush, a Republican, and the other two were appointed by President Bill Clinton, a Democrat.

No ruling is expected for months, and legal experts expect an appeal to the U.S. Supreme Court regardless of which side wins.